Oxandrolone was established in 1964 in the depths of the American company “Searle» (Searle Co) and sold under the trademark “Anavar” in the US market more than 25 years. The creators of the steroid can rightly be regarded as the two employees, “Searle” – Young and Pappo, they developed the idea of introduction of hetero atoms in the steroid skeleton. After a series of not very successful attempts oxygen was introduced into the second position (ring A), which gave a result of the drug, later called oxandrolone.
The first experiments on rats have shown a sharp decline in experimental animals the nitrogen in the urine, which is an indication of increasing protein synthesis muscle fibers, but at the same time, the almost complete lack of tangible growth in both muscles (remember, in this kind of experiment is considered a muscle levator ani), and prostate.
July 1, 1989 the production of Anavar was phased out of the US, but its analogues continue to be issued until now. In recognition of the famous bodybuilder Krischena Mike (Mike Christian), it Anavar was his first anabolic steroids and achieved impressive increases of in strength and mass. History is silent about the dosage used by the Mr. Krischen, but he still remains almost the only athlete who is able to.
Unlike the vast majority of anabolic steroids, the main use of oxandrolone lies beyond sport – this drug is very widely used in medical practice. As for sports, there oxandrolone is used mainly in track and field, swimming etc. In power sports – bodybuilding, powerlifting, barbell, strongman – where it is used as a rarely. The main obstacle to its use sportsmenami- “siloviki” – a very high price (if the same athletes may cost 2-4 oxandrolone tablets a day, the “siloviki” required dose several times higher, about dosages see. Below).
With the ability to greatly enhance the synthesis of creatine phosphate muscle fibers, oxandrolone may provide a significant increase in power, without leading to a significant increase in weight – a quality that can be appreciated by athletes lighter weight categories. That gain in terms of power – the main advantage of oxandrolone as regards the set weight, it is hardly justified to use for this purpose is so expensive means. Despite the fact that very good oxandrolone stabilizes the androgen receptor (perhaps even better than testosterone), its application even at very high doses does not lead to a significant increase in muscle mass.
At the same time oxandrolone is perhaps the most powerful anti-catabolic, it very well “occupied” cortisol receptors, as their antagonist (prevents activation). For this reason oxandrolone is often used in between cycles to maintain gain muscle mass (here it is usually combined with Andriol – testosterone undecanoate), and in preparation for a competition, if the use of testosterone propionate is undesirable. By the way, in addition to the anti-catabolic activity, oxandrolone has another useful feature – it has absolutely no influence on the body’s production of testosterone.
Yet the main purpose of oxandrolone – preparation for competitions. Several studies have noted the presence of oxandrolone ability to burn fat, this may be due to the ability of the drug is very well stabilize the androgen receptor. The use of oxandrolone results in marked upregulation (increase the amount) of androgen receptors, including those in the fatty tissue – one more fact testifying to the presence of fat-burning properties of the drug. On the anti-catabolic activity of the drug, the property is also crucial in a period of “drying” has been said.
The use of oxandrolone, together with fluoxymesterone or Drostanolone increases the stiffness of the muscles that useful to the eve of the competition. Finally, metabolites oxandrolone completely leave the body for 10-12 days, so that the drug can be taken before the event, which will be carried out doping controls.
It is certainly positive features of oxandrolone should include the almost complete lack of steroid side effects – along with methenolone oxandrolone is the safest drug. Oxandrolone not aromatize in any dosage does not exert any influence on the production of endogenous testosterone, so it is possible, as has been said, to use the intervals between cycles in order to avoid loss of muscle mass.
The only thing that can spoil the impression of the product – is the presence of an alkyl group in position 17, in other words, oxandrolone is potentially dangerous to the liver. However, the case of violation of the liver due to the fault of this steroid, as far as I know, never mentioned. Another not very nice touch oxandrolone – the ability to provoke diarrhea, especially true for the following doses. However, the diarrhea occurs still a minority of athletes who take oxandrolone, and for all the troubles that accompany this disorder, to life-threatening it can not be attributed.
It should be noted that the normal value from the drug strength sports athletes to be expected only from the daily dose of 50 mg of oxandrolone. But even when taking 150 mg of the drug daily, as they say, without the “support” from the other anabolic steroids hope for any significant increase in muscle mass is not necessary.
In between cycles the daily dose can be reduced to 30-40 mg. Based on the half-life of 8-9 hours oxandrolone, its daily dose may be divided into three equal parts and is taken at regular intervals.
Combination with other drugs
About oxandrolone combined with other anabolic steroids is a little earlier, but it is useful to repeat the above. The drug can be used as a “support” in massonabornyh cycles, which are based on testosterone or nandrolone, quite good, and can be regarded as a purely “oral” cycles in which the reception is combined with the reception of oxandrolone methandrostenolone or oxymetholone. But it still can not in any case be considered the main purpose of oxandrolone.
At the stage of “drying” oxandrolone makes a good background for clenbuterol, from other drugs in that period should be used stanozolol or fluoxymesterone. To increase power performance without significant increases of the mass of oxandrolone is best to combine with the same stanozolol. On the eve of the competition with a combination of drug Drostanolone or fluoxymesterone help give your muscles stiffness. Finally, in the interval between cycles of oxandrolone can be combined with taking Andriol or methenolone.
The use of women
Oxandrolone – almost ideal drug for use not only by women but also by young athletes, this is his another huge advantage. Steroid not lead to virilization in general, it has no effect on the so-called “zone of growth” in young people. As for dosages, for the women, they must be somewhat lower and lie within 20-40 mg per day.