Clenbuterol being beta-2 agonist, acts as a fat burner binding to beta-receptors type 2 in adipose and muscle tissue of the human body. After clenbuterol binds to the receptor triggers a cascade of biochemical reactions that lead to increased synthesis of cAMP (cyclic adenosine monophosphate). cAMP in turn activates enzymes that mobilize fatty acids from adipocytes (fat cells).
Anabolic and anti-catabolic effects of clenbuterol
The action of clenbuterol on the beta-2-adrenergic receptors of the presynaptic membrane is enhanced release of noradrenaline and adrenaline, which have a powerful fat-burning effect. Clenbuterol Wales increases basal metabolism by 20-30% from baseline.
Clenbuterol price inhibits the activity of lipoprotein lipase, resulting in the deposition of fat in adipose tissues becomes impossible. Acting beta-2 adrenoceptor central nervous system, this drug increases the secretion of thyroid hormones – the natural fat burners body.
A unique feature of clenbuterol is that it is not only a powerful fat burner, but also has a strong anti-catabolic effect, protecting muscles from breaking down, which is very important during weight loss and drying in bodybuilding. Studies have found that the anti-catabolic effect of the drug due to the blocking of Ca ++ dependent and ubiquitin-proteasome proteolysis.
A new study in 2012 (Francesca Wannenes, Loretta Magni) confirms the ability of clenbuterol blocking mechanisms of muscle atrophy.
Due to the above mechanisms, the drug has a moderate anabolic effect that is proven in animal experiments and practical application in bodybuilding. Some writers argue that large doses of clenbuterol may have catabolic effects, but this statement is untrue. To do this, no physiological or practical justification.
Given the fact that the preparation hardly interacts with beta-1-adrenergic receptors occur bronchiectasis and facilitating breathing, and also much lower incidence of side effects in cardiovascular system as compared to non-selective agonist, such as ephedrine.
How to take:
In men, the recommended dose of clenbuterol for drying and losing weight is 120 – 140 micrograms per day. In women, the average dose of clenbuterol for drying and weight loss is 80-100 mg per day. Course clenbuterol has its subtle features which must be strictly observed to avoid side effects.
Duration of clenbuterol is usually 2 weeks, and then produces addiction (tolerance receptors) and efficiency is reduced. Then you must make a 2 week break and then repeat the course. The duration of the course and effectiveness of clenbuterol can be enhanced by the inclusion of ketotifen. Sometimes, to avoid adaptation of receptors recommended pulse rate – 2 days of reception, 2 days of rest, however, this scheme is less effective.
Remember during the cycle to take a sufficient amount of protein, BCAA and other blockers cortisol, it will significantly improve the outcome. Observe the appropriate diet for weight loss and drying.
In 2010, a study, which revealed a synergistic effect when combined with anabolic steroids, which confirms the feasibility of incorporating the drug at the end of the course the AU
Fat burning and drying of muscles
Anabolic effect (weakly expressed)
The low incidence of side effects, the almost complete absence of health hazards (practice shows that irreversible side effects is almost completely absent) and the wide range of positive effects of clenbuterol do one of the best fat burners bodybuilding.